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导师介绍

姚礼山
来源: 发布日期:2021/07/26 点击量:



BA7C17

电子邮箱: yaols@qibebt.ac.cn

电话:0532-80662792 

个人经历:

     2010-06至今, 中科院青岛生物能源与过程研究所,研究员;

    2006-062010-05,美国国立健康中心, 博士后;

    2001-072006-05 密西根州立大学,物理化学博士。

承担项目:

 主持中组部WR人才计划项目

 山东省泰山学者特聘专家项目(优秀)

 国家重点研发计划子课题2项

 国家自然科学基金面上项目4

 国家自然科学基金国际合作项目1

 中科院BR人才计划项目

 山东省杰出青年基金等项目

研究方向:

1)人工酶和抗体酶药物设计与研发;

2)蛋白质结构和动态性研究的新技术和新方法发展;

代表性论文:

(1)Xiangfei Song#,; Mengting Wang#;Xiaoxu Chen,; Xueying Zhang,; Ying Yang,; Zhijun Liu,; Wang; Lishan Yao*,.  Quantifying Protein Electrostatic Interactions in Cells by Nuclear Magnetic Resonance Spectroscopy.J. Am. Chem. Soc.,2021, doi: org/10.1021/jacs.1c10154.

(2)Mengting Wang#,;Xiangfei Song#,;jingfei Chen, Xiaoxu Chen,Xueying Zhang,Ying Yang,Zhijun Liu,and Lishan Yao*, Intracellular Environment Can Change Protein Conformational Dynamics in Cells through Weak Interactions.Science Advances 2023, http://www.science.org/doi/10.1126/sciadv.adg9141

(3) Song Xiangfei; LvTianhang; Chen Jingfei; Wang Jia; Yao Lishan*. Characterization of Residue Specific Protein Folding and Unfolding Dynamics in Cells. Journal of the American Chemical Society, 2019, 141 (29), 11363-11366.

(4) Li Jingwen#; Wang Yefei#; An Liaoyuan; Chen Jingfei;Yao Lishan*. Direct Observation of CH/CH van der Waals Interactions in Proteins by NMR. Journal of the American Chemical Society, 2018, 140, 3194-3197.

(5) Zhang Ning#; An Liaoyuan#; Li Jingwen; Liu Zhijun; Yao Lishan*. Quinary Interactions Weaken the Electric Field Generated by Protein Side-Chain Charges in the Cell-like Environment. Journal of the American Chemical Society, 2017, 139, 647-654.

(6) Li Jingwen#; Wang Yefei#; Chen Jingfei; Liu Zhijun; Bax Ad; Yao Lishan*. Observation of alpha-Helical Hydrogen-Bond Cooperativity in an Intact Protein. Journal of the American Chemical Society, 2016, 138, 1824-1827.

(7)An Liaoyuan; Wang Yefei; Zhang Ning; Yan Shihai; Bax Ad; Yao Lishan*. Protein Apparent Dielectric Constant and Its Temperature Dependence from Remote Chemical Shift Effects.Journal of the American Chemical Society, 2014, 136, 12816−12819.

(8)WangYefei#; An Liaoyuan#; Yang Ying; Yao Lishan*.Generating FiveIndependent Molecular Alignments for Simultaneous Protein Structure andDynamics Determination Using Nuclear Magnetic Resonance Spectroscopy. Analytical Chemistry, 2020,92(23):15263-15269.

(9) Li Jingwen#; Chen Jingfei#;An Liaoyuan; Yao Lishan*. Polyol and sugar osmolytes can shorten protein hydrogen bonds to modulate function. Communications Biology, 2020, 3(1): 528.

(10) Zhang Ning#; Wang Yefei#; An Liaoyuan; Song Xiangfei; HuangQingshan; Liu Zhijun; Yao Lishan*. Entropy Drives the Formation of Salt Bridges in the Protein GB3.AngewandteChemie International Edition, 2017, 56, 7601-7604.


授权发明专利:

1.姚礼山,宋乡飞,王业飞,一种改良性能的黄素单核苷酸结合荧光蛋白质,2012年,中国,ZL 201210160241.3.

2.姚礼山,宋乡飞,王业飞,张树军,张雨,洪景波.一种改良性能的纤维素内切酶Cel7B突变体. 2015年,中国, ZL 201510049724.X



 

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